Wolves host Leicester City at Molineux in the Premier League. A Wolves win would see them climb above their visitors to eighth in the table.
Harrogate Town, still harbouring promotion hopes, go toe-to-toe with Hartlepool United in the Vanarama National League. Michael Woods faces his former club for the first time.
Swansea City take on Sheffield United at the Liberty Stadium in the Sky Bet Championship. The promotion-chasing Blades are looking for a fifth straight league win.
Arsenal and Chelsea, both vying for a top-four spot, meet in the Premier League at the Emirates Stadium. The Gunners would close the gap on Chelsea to just three points with a win.
The first fixture after the winter break for the Bundesliga leaders as Borussia Dortmund take on RB Leipzig. The hosts were defeated 4-1 in Dortmund on the opening weekend.
Huddersfield Town meet Manchester City at John Smith's Stadium in the Premier League. City need three points here as they look to keep the pressure up on Liverpool at the top.
Rennes play host to Montpellier in Ligue 1 at Roazhon Park. Rennes have won four of their last five league matches, but come into this one on the back of a defeat to Guingamp.
Nuremberg take on Hertha Berlin as the Bundesliga returns after the winter break. The hosts are winless in 11 league matches, losing each of the last four without scoring.
Fulham take on Tottenham Hotspur at Craven Cottage in the Premier League. Spurs will be looking to respond after losing last week to Manchester United.
Caen and Marseille clash in Ligue 1. Rudi Garcia's men have enjoyed playing at the Stade Michel-d'Ornano in recent times, winning eight and drawing one of their last nine visits.
Schalke and Wolfsburg meet at the Veltins-Arena in the Bundesliga. The hosts look to move further away from the danger zone at the expense of Champions League-chasing Wolfsburg.
Both Saint-Etienne and Lyon look to bolster their Champions League qualification hopes as they square-off in Ligue 1. A win will see Lyon leapfrog their opponents in the table.